Traditionally, antibiotics have come from natural sources, for instance penicillin, or are modified to achieve broad-spectrum activity. Using a so-called ‘lock and key’ mechanism at the ...

The University of Illinois at Chicago has developed macrolones, antibiotics that disrupt two cellular mechanisms in bacteria. According to researchers, this dual action makes bacterial resistance ...

When confronted with an antibiotic, toxic substance, or other source of considerable stress, bacteria are able to activate a ...

One method for overcoming current bacterial resistance mechanisms is to explore new biochemical targets involved in essential cellular processes, however there are many challenges in developing ...