The asymmetric segregation of chromosomes during cell division is proposed to be a characteristic of stem cells, and this 'immortal strand hypothesis' was proposed as a way in which stem cells ...

At the same time, the field has become more multidisciplinary — advances in the understanding of developmental and stem-cell biology ... reorganization, asymmetric cell division in different ...

New research reveals how a localized source of a signaling molecule directs a dividing stem cell to produce two different cells—one identical to its parent, the other a more specialized cell type—and ...

We know that hematopoietic stem cells (HSCs) must negotiate a delicate balance between symmetric division and asymmetric division in order to maintain self-renewal of the HSC compartment and continued ...

Our laboratory studies both stem cell-intrinsic and extrinsic mechanisms altering tissue renewal capacity, and how such mechanisms ultimately result in the functional decline we recognize as aging.