New insights into the impact of checkpoint inhibitors on the immune system may enhance cancer treatment strategies. A ...

Studying patients with PD-1 or PD-L1 deficiency may help inform new approaches to fine-tuning immunotherapies to maximise ...

Co-author Dr Kenji Chamoto, from Kyoto University, says, “PD-1 inhibition has a ‘yin and yang’ nature: it activates anti-tumour immunity but at the same time impedes B-cell immunity.

A multinational collaboration has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint inhibitors experience increased susceptibility to ...

Co-author Dr Kenji Chamoto, from Kyoto University, says, “PD-1 inhibition has a ‘yin and yang’ nature: it activates anti-tumour immunity but at the same time impedes B-cell immunity. And this duality ...

A multinational collaboration co-led by the Garvan Institute of Medical Research has uncovered a potential explanation for why some cancer patients receiving a type of immunotherapy called checkpoint ...

Humoral immunity refers to antibody-mediated immune ... During the antigen-dependent phase of B cell development, clones expressing high-affinity B cell receptors are transferred from light ...

"Also, the original vaccines focused on B cell-mediated antibody responses for developing immunity. We now know that ...