Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

BRCA1 (breast cancer 1, early onset) is a tumor suppressor that probably has a DNA repair function. BRCA1 is expressed at high levels in the T cell lineage, however its function during thymocyte ...

For cancer-suppressor genes like BRCA1, researchers have long hypothesized that a single healthy copy could still guard against tumor development. Yet women with one harmful BRCA1 mutation are far ...

More information: Ksenija Nesic et al, BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor ...

In high-income countries, most patients with a DNA repair deficiency known as HRD – which can be caused by BRCA1 or BRCA2mutations – are now receiving this treatment. However, drug resistance ...