Similarly to mice that lack other regulators of the cytoskeleton, HEM1-deficient T cells showed decreased activation and proliferation compared with wild-type T cells. Surprisingly, some T-cell ...

The cytoskeleton is a network of filamentous and tubular protein structures that support cell shape, intracellular compartmentalisation and trafficking, cell migration and cell division.

We recently discovered that these structures are essential for the establishment of reticular adhesions. In our lab, we aim to elucidate the interplay of clathrin structures with the actin ...