T cell lineage maturation is a highly regulated process requiring intact DNA repair capacity 1,2. BRCA1 (breast cancer 1, early onset) is a tumor suppressor that probably has a DNA repair function.

Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation in prostate ...

BRCA1 belongs to a family of tumor suppressor genes, which make proteins that mend damaged DNA. Generally, a single functioning copy of a gene is sufficient to ensure normal function even when the ...