The EGF receptor (EGFR) was the first receptor to ... II and III trials with this drug in NSCLC, which have led to the worldwide approval of erlotinib treatment as monotherapy for therapy ...

They found both previously known and novel mutations significantly linked to EGFR activation and drug response ... EGFR signaling and did not analyze receptor interactions or heterozygous effects.

Why then would most of the crystallized forms of EGFR show the receptor in its active conformation? Most likely, the crystallization process necessary for analyzing protein structure caused a high ...

South Korea-based biotechnology company Bridge Biotherapeutics has begun a Phase I/II clinical trial of BBT-207 to treat non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ...