We have identified 14 mutations of the factor VIII (F8) gene from a panel of 107 patients with hemophilia A and have characterized these gene defects by restriction analysis, oligonucleotide ...

People with hemophilia A have a genetic change on the F8 gene of their X chromosome that affects the production of clotting factor VIII. Without enough clotting factor VIII, coagulation is ...

Hemophilia A is a rare bleeding disorder caused by mutations in the F8 gene, leading to insufficient clotting factor VIII (FVIII) in the bloodstream. FVIII is crucial for normal blood clotting ...