A recent innovation from Johns Hopkins researchers enables deeper insights into gene function and disease-linked mutations ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

Johns Hopkins researchers have developed a powerful new AI tool called Splam that can identify where splicing occurs in genes—an advance that could ...

Second, it has been estimated that 15% of the point mutations that cause genetic diseases in humans alter the normal splicing pattern 6. Splice variants that are disease specific can be excellent ...

Over millions of years, changes in DNA allow animals to evolve ... proteins from the same gene is called "alternative splicing," and it is one of the reasons human physiology is so complex.

Combining these two sets, we identified 582 different human genes showing unequivocal alternative splicing via exon insertion, extension, truncation or deletion. This represents 22% of genes ...

Around 25 million years ago, an evolutionary split occurred between our ancestors, the precursors of humans ... the TBXT gene ...