These decrements in HRQOL vary across the spectrum of clinical phenotypes according to the presence and frequency of gout symptoms and signs. Patients with confirmed tophi and more frequent acute ...

Tophaceous gout is a severe form of gout. It results when uric acid crystals form, leading to growths called tophi around the ...

The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.

an increased frequency of gouty attacks and with the presence of tophi. In the De Vera et al. study, information about these disease features was lacking, and the poor case definition of the gouty ...

and chronic gouty arthritis with multiple gouty tophi. He had also had hyperuricemia for many years, with uric acid concentrations of up to 9.8 mg/dl. Initial treatment with febuxostat 80 mg bid ...

Tophi are a symptom of gout. They are large, hardened masses of uric acid crystals within and around the joints. These masses can cause pain, joint deformity, and limited range of motion.