These increases were associated with chromatin remodelling, as an increase in histone H3 Lys4 (H3K4) methylation at GABAergic gene loci was also observed over this period of development.

Figure 1: Histone H3K4 methylation by yeast COMPASS and mammalian COMPASS-like complexes. Figure 2: Structural basis for histone H3, MLL1 Win and WDR5 Ala12–Pro17 recognition by WDR5.