The basal secretion of glucagon stabilizes blood glucose levels, counterbalancing the basal secretion of insulin. 1 Glucagon stimulates the liver to produce more glucose, thus maintaining glucose ...
Currently, a plausible hypothesis is that a decrease in intraislet insulin concentrations triggers glucagon release,1 but this mechanism has not been definitely proven in humans, and at this point ...
New entrants: incretin-based therapies Incretins are peptide hormones that stimulate insulin secretion, inhibit glucagon secretion and promote satiety after nutrient ingestion. The short-lived ...
On day 1, GLP-1 was infused to stimulate endogenous insulin release and suppress endogenous glucagon. On days 2–5, pancreatic endocrine clamps were performed using somatostatin infusions of ...