Zhou, Q.H., Li, H.M., and Xue, D. (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669 ...

Damage to this layer—lysosomal membrane permeabilization, or LMP for short—can trigger inflammation and even lead to cell death. In humans, LMP is particularly deleterious in nerve cells ...

More information: Xiaowen Ma et al, Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation ...

Autophagy targets portions of cytoplasm, damaged organelles and proteins for lysosomal degradation and has crucial roles in development and disease ... fragments of mitochondria and endoplasmic ...

My investigation of a newly discovered erythropoietic disease allele of ClpX indicates that ClpX may conditionally ... will reveal how the mitochondrion makes specific and crucial regulatory decisions ...

mitochondrial respiration and ATP production, fusion/fission impairment, mtDNA damage. The final result is the loss of the mitochondrial membrane potential, causing the induction of mitophagy and ...

When mitochondria are damaged, cytochrome c can induce a signal that leads to apoptosis. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert!

The Lysosomal Metabolomics and pH Core’s overarching goal is to understand the mechanistic link between lysosomal activity and aging in Alzheimer’s Disease. To accomplish this, the core will support ...