We hypothesized that NGS would identify patients with alterations in mismatch repair (MMR) genes and that these patients would have higher rates of MMR protein loss by IHC. This would support the ...

Figure 2: Immunohistochemistry for DNA mismatch ... screening by either immunohistochemical analysis of tumor MMR protein expression or by tumor genotyping for microsatellite instability is ...

IHC-MMR detects defective MMR proteins, while NGS-MSI measures MSI, the genomic result of dMMR. By directly comparing the concordance of NGS-MSI and IHC-MMR results in tumor samples tested by a ...

In total, 474 colon cancers diagnosed ≥ age 50 were evaluated with correlation between clinicopathologic variables and immunohistochemical MMR protein expression. Results: Female sex ...