The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

Knowledge of a drug's mechanism of action enables better dosing through monitoring of the drug's effects on the target pathway in the patient. For example, the proper statin dosage for a given ...

With only a few exceptions, these drugs were discovered by screening in animal models which do not discriminate on the basis of mechanism of action. Over the last 35 years, over 34,000 ...

We suggest, however, that a different mechanism may underlie much of the therapeutic action of rituximab in autoimmune diseases: binding of tens of thousands of rituximab−IgG molecules to B ...

According to a new study published in Nature Communications, researchers at the Department of Laboratory Medicine, Karolinska ...

Lenacapavir, a treatment administered subcutaneously every six months, is capable of preventing infection with very high ...

With this unique mechanism of action, the bioadaptor addresses the shortcomings of drug-eluting stents and bioresorbable scaffolds, translating to remarkably low clinical event rates that plateau ...