"Monocytes were thought to play a limited role in cancer immunity," explains Guillem Estivill, co-first author of the study and a student in the Vienna BioCenter Ph.D. Program. "Now we show how ...

Cancer cells often become unresponsive to multiple types of therapy. It emerges that these ‘cross-resistant’ tumour cells release lipids that reprogram cells called monocytes to stop them from ...

We were also the first to report that tumor growth induces monocyte-derived tumor-associated macrophages (TAMs) supported by juxtacrine Notch signaling by cancer cells. We found that TAMs can be ...

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse ...