The identity of a neuron is determined by the so-called terminal differentiation genes (TDGs), which are activated by specific transcription factors. It is largely unknown how the TDGs are ...

Loss of Notch signaling therefore causes excess neural differentiation. A second broad category is “inductive” signaling, whereby activation of Notch induces the expression of molecules with ...

Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...

DEAD-box helicase 17 (DDX17) is an RNA helicase involved in the early phases of neuronal differentiation. Researchers have identified a total of 13 patients presenting with neurodevelopmental ...

In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...

A recent study explores how MYCN-driven neuroblastoma hijacks the m6A modification process to prevent proper cell ...