生命科学Life science2024年11月21日，中山大学孙逸仙纪念医院蒋琳加研究员在Cell Press细胞出版社旗下期刊Trends in Cell Biology杂志发表了题为 “Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance”的综述文章。SHP1和SHP2是非受体蛋白酪氨酸磷酸酶（no ...

Recent research has observed that chemical modifications called phosphorylation of proteins in brain neurons dynamically ...

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance ...

and dephosphorylation (catalyzed by protein phosphatases). Protein kinases mediate most of the signal transduction events in cells by phosphorylation of specific substrates - modifying their activity, ...

Blocking the activity of protein phosphatase 1 reduced the dephosphorylation of Ser9 during LTD, indicating that this enzyme increases GSK3β activity during LTD. The authors applied stimuli to ...

Children’s of Alabama recently received two grants totaling $60,000 from the Vince Lombardi Cancer Foundation’s Starr ...

Kinases, enzymes that phosphorylate proteins, generally control the amplitude of a signal response, whereas phosphatases, enzymes that dephopshorylate proteins, are thought to be important for ...

Our longstanding interest is the global and comprehensive understanding of how key cellular signaling molecules; protein kinases, protein phosphatases and transcription factors mediate their signaling ...

Northwestern Medicine scientists have uncovered new details about how the spinal column forms in developing vertebrates, ...