The basic concept of protein targeting and translocation across biological membranes emerged in the 1970s with the discovery of cleavable N-terminal signal sequences 1.Specialized factors that ...
the drug has to be modified to include the appropriate signal to target it to the subcellular site, without compromising its functional moiety. Protein modifications or lipid conjugations that ...
They found that only specific sequences present in the protein structure of HSR201 allowed it to enter the peroxisomes, thereby identifying a unique targeting signal known as the peroxisomal ...