The RAMQ medical services database contains information from physicians ... or β-blockers) or spironolactone. Patients were considered new users if the first script for one of these treatments ...

In addition, comorbidity level, estimated by the modified Von Korff score, was higher for patients using spironolactone. A large proportion of spironolactone users received concomitant treatment ...

showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure. The drug can sometimes cause life-threatening hyperkalemia, however, when used in ...

Aldosterone is an important mediator in the pathogenesis of heart failure, and increased plasma aldosterone levels are associated with a poor prognosis. Aldosterone-receptor blocking drugs can ...