In addition, comorbidity level, estimated by the modified Von Korff score, was higher for patients using spironolactone. A large proportion of spironolactone users received concomitant treatment ...

showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure. The drug can sometimes cause life-threatening hyperkalemia, however, when used in ...

Aldosterone is an important mediator in the pathogenesis of heart failure, and increased plasma aldosterone levels are associated with a poor prognosis. Aldosterone-receptor blocking drugs can ...

stabilized potassium levels among patients with heart failure with reduced ejection fraction (HFrEF) during spironolactone optimization, a prospective, randomized-withdrawal trial showed.

The RAMQ medical services database contains information from physicians ... or β-blockers) or spironolactone. Patients were considered new users if the first script for one of these treatments ...