Recent genome-wide analyses of alternative splicing indicate that 40–60% of ... a very different process than traditional molecular biology. It can be simultaneously 'more rigorous' (much ...

A comprehensive study identifies sequence features that predict tissue-specific alternative splicing. In contrast to transcription and translation, in which the flow of information from DNA to pre ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

The most complex molecular machine in human biology Every cell in the human ... which then undergoes a crucial editing process called splicing. During splicing, non-coding segments of RNA are ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions. Imogen is a PhD student in the Division of Structural ...

The sheer number of components involved and the intricacy of its function has meant the spliceosome has remained elusive and uncharted territory in human biology—until now. The blueprint reveals ...