Calcium is required by two proteins, troponin and tropomyosin, that regulate muscle contraction by blocking the binding of myosin to filamentous actin. In a resting sarcomere, tropomyosin blocks ...

Simplified schematic of actin backbones, shown as gray chains of actin molecules (balls), covered with smooth tropomyosin filaments. Troponin is shown in red (subunits not distinguished).

Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties and tropomyosin’s ability ...

Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties and tropomyosin’s ability ...