The death toll from fentanyl is falling as communities flood the streets with naloxone, an overdose-reversal drug. But deadly ...

Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...

Avoid concomitant mixed agonist/antagonist opioids (eg, butorphanol, nalbuphine, pentazocine) or partial agonist (eg, buprenorphine); may reduce effects and/or precipitate withdrawal symptoms.

Employing a nurse care manager to work with patients who have an opioid addiction and prescribing partial or full opioid agonists can help more people enter treatment in primary care settings ...

Xylazine and medetomidine also don’t cause respiratory arrest – the usual cause of death from a fentanyl overdose. They ...

Vertex Pharmaceuticals’ investigational non-opioid analgesic suzetrigine failed to outperform placebo. Investors voiced their concerns as the company’s share price fell 13% in premarket trading.

Pfizer and Lilly have filed for approval of a 2.5 mg subcutaneous dose, which had mixed results ... type 4 (SSTR4) agonist in phase 1 testing that also has potential as a non-opioid painkiller.

As fentanyl continues to drive the American opioid crisis, restaurant and bar workers are emerging as essential players in ...

In our ongoing look at treating substance abuse in America, we turn to the most commonly used drug, and one of the deadliest: ...

St John's wort is an herbal supplement that has been used for centuries to boost mood. Even today, many people use it as a ...

The company said it was “putting the brakes on the opioid epidemic” by making it harder to get potentially dangerous amounts of the drugs. The announcement, which came after pressure from ...