The company is hoping to show GT-02287 can slow Parkinson's progression by restoring function of GCase, an enzyme encoded by ...

New therapies that are less intrusive but more lasting than current interventions promise to arrest and even reverse neurodegeneration.

Mitochondria are the main source of energy for cellular activity. Their functional damage or deficiency leads to cellular deterioration, which in turn triggers autophagic reactions. Taking ...

The effect of astrocytic mitochondrial dysfunction in the pathophysiology and treatment strategies of Alzheimer’s disease and depression is discussed. Greater attention is needed to investigate the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lysosomal damage induces stress granule (SG) ...

But while constraint models have been highly effective for identifying disease-causing variants in the nuclear genome, they have not been useful for mutations in the mitochondrial genome, a source of ...

mitochondrial respiration and ATP production, fusion/fission impairment, mtDNA damage. The final result is the loss of the mitochondrial membrane potential, causing the induction of mitophagy and ...

Mitophagy plays an important role in mitochondrial homeostasis. In yeast, the phosphorylation of the mitophagy receptor Atg32 by casein kinase 2 is essential for mitophagy. This phosphorylation is ...

These components are engulfed by a specialised structure known as the autophagosome and delivered to the digestive lysosome. This essential ... the specific autophagy of mitochondria. Dysfunctional ...