Review on the role of glutathione on oxidative stress and infertility
The protective action of glutathione against reactive oxygen species (ROS) is facilitated by the interactions with its associated enzymes, such as glutathione peroxidase and glutathione reductase. In animal tissues, glutathione peroxidase, a selenium containing anti-oxidant enzyme, catalyzes the reduction of hydrogen peroxide and lipid peroxide ...
The role of glutathione and glutathione peroxidase in …
Overproduction of reactive oxidative species (ROS) and reactive nitrogen species (RNS) including superoxide (O 2 •-), and the loss of nitric oxide (NO) bioavailability is a characteristic of endothelial dysfunction. The GSH/GPX system play an important role in eliminating ROS/RNS.
Glutathione-dependent redox balance characterizes the distinct
2022年4月4日 · Here we show, by studying mice with B cell-specific ablation of the catalytic subunit of glutamate cysteine ligase (Gclc), that glutathione synthesis affects homeostasis and differentiation of...
Role of glutathione depletion and reactive oxygen species
2002年2月25日 · After BSO treatment, there was an early decline in cellular glutathione (GSH), followed by an increase in reactive oxygen species (ROS) production, which induced a variety of apoptotic signals...
Regulatory functions of ROS dynamics via glutathione …
2021年9月19日 · In this study, ROS dynamics, the glutathione redox status, the expression and subcellular localization of glutathione peroxidases (GPXs), and the effects of inhibitors of ROS-mediated metabolism were investigated along with fertilization and early zygotic embryogenesis in rice (Oryza sativa).
Glutathione peroxidase 4 overexpression inhibits ROS-induced …
2018年2月20日 · In the present study, we clarify that GPX4 overexpression contributes to poor prognosis in DLBCL via inhibition of reactive oxygen species (ROS)-induced cell death by clinicopathologic study and...
Application of glutathione depletion in cancer therapy: Enhanced ROS ...
2021年10月1日 · GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed.
The functions of glutathione peroxidase in ROS homeostasis
2020年11月4日 · Glutathione peroxidase (GPX) is one of the most important antioxidant enzymes for maintaining reactive oxygen species (ROS) homeostasis. Although studies on fungi have suggested many important physiological functions of GPX, few studies have examined the role of this enzyme in Basidiomycetes, particularly its functions in fruiting body ...
NOX-like ROS production by glutathione reductase - Cell Press
2022年10月21日 · In organisms from bacteria to mammals, NADPH oxidase (NOX) catalyzes the production of beneficial reactive oxygen species (ROS) such as superoxide (O 2− ). However, our previous research implicated glutathione reductase (GR), a canonical antioxidant enzyme, as a source of extracellular superoxide in the marine diatom Thalassiosira oceanica.
Glutathione Homeostasis and Functions: Potential Targets for …
Glutathione is responsible for helping to maintain redox balance by directly or indirectly interacting with ROS, and is also involved in detoxification of electrophiles either via direct interactions or via enzyme-catalysed conjugation.