Anti-histone antibodies - Wikipedia
Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. [1] They were first reported by Henry Kunkel , H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60.
Anti-histone Abs - Lab Results explained | HealthMatters.io
Elevated Anti-histone Antibodies (Anti-histone Abs) refer to an increased presence of autoantibodies that specifically target histone protein subunits in the bloodstream. These antibodies are a subset of the anti-nuclear antibody (ANA) family.
Anti-Histone Antibodies - an overview | ScienceDirect Topics
Anti-histone (Nucleosome). Anti-histone antibodies target the protein components of nucleosomes, the DNA-protein complexes that form the substructure of transcriptionally inactive chromatin.
Histone Antibody - Understand the Test - Testing.com
2021年1月27日 · Histone antibodies are proteins produced by the immune system that mistakenly target the body's own tissues. A histone antibody test detects these autoantibodies in the blood to help diagnose drug-induced lupus,
012518: Antihistone Antibodies - Labcorp
Antibodies to histones are detected in approximately 30% to 60% of patients with systemic lupus erythematosus (SLE), but their presence in about 95% of patients with drug-induced lupus is more important diagnostically.
Anti-Histone Antibodies - an overview | ScienceDirect Topics
Anti-histone antibodies (AHA) occur in a number of clinical conditions, primarily in systemic lupus erythematosus and drug-induced lupus, and also in other systemic and organ-specific autoimmune diseases, and certain neurological and infectious diseases.
Use and Interpretation of Rheumatologic Tests: A Guide for …
In recent years, several new autoantibody tests have been developed and are being used in the field of rheumatology, including the antineutrophil cytoplasmic antibody (ANCA) and myositis-specific antibodies such as anti-Jo1. Positive test results for ANCAs reveal one of two basic staining patterns: cytoplasmic (c-ANCA) or perinuclear (p-ANCA).
Histone Antibody - an overview | ScienceDirect Topics
Antibodies to histones are generally measured by means of specific ELISAs, using purified histones as antigens. Care has to be taken regarding the purity of commercial histone preparations. Antihistone reactivity is also readily detectable in immunoblotting assays, using nuclear extracts as antigen. CASANDRA C. VAN BAVEL, ...
Antibodies to histone in the pediatric population: a retrospective ...
Anti-histone antibodies were observed in a variety of diagnoses in the pediatric population, many of which are considered benign or not rheumatologic. Most frequently, anti-histone antibodies were present in patients without underlying autoimmunity, especially at weak titers.
An interactive database for the assessment of histone antibody ...
The Histone Antibody Specificity Database represents an invaluable resource and tool for the scientific community who rely on histone PTM antibodies as detection reagents in chromatin and epigenetics research.