2-Oxoglutaric acid | C5H6O5 | CID 51 - PubChem
2-oxoglutaric acid is an oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle. It has a role as a fundamental metabolite. It is functionally related to a glutaric acid. It is a conjugate acid of a 2-oxoglutarate (1-).
α-Ketoglutaric acid - Wikipedia
α-Ketoglutaric acid (also termed 2-oxoglutaric acid) is a dicarboxylic acid, i.e., a short-chain fatty acid containing two carboxyl groups (carboxy groups notated as CO 2 H) with C, O, and H standing for carbon, oxygen, and hydrogen, respectively (see adjacent figure).
Alpha-Ketoglutarate: Physiological Functions and Applications
Alpha-ketoglutarate (AKG), also referred to as 2-ketoglutaric acid, 2-oxoglutamate, 2-oxoglutaric acid, oxoglutaric acid and 2-oxopentanedioic acid (Harrison and Pierzynowski, 2008), is a rate-determining intermediate in the tricarboxylic acid (TCA) and has a crucial role in cellular energy metabolism. In cellular metabolism, the generation and ...
The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite
The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic pathways. This compound is a key intermediate of one of the most fundamental biochemical pathways in carbon metabolism, the tricarboxylic acid (TCA) cycle.
2-oxoglutaric acid (CHEBI:30915) - EMBL-EBI
α-Ketoglutaric acid (also termed 2-oxoglutaric acid) is a dicarboxylic acid, i.e., a short-chain fatty acid containing two carboxyl group s (carboxy groups notated as CO2H) with C, O, and H standing for carbon, oxygen, and hydrogen, respectively (see adjacent figure). However, almost all animal tissues and extracellular fluids have a pH above 7.
2 Oxoglutaric Acid - an overview | ScienceDirect Topics
Alpha-ketoglutarate (AKG), also known as 2-oxoglutarate (IUPAC name: 2-oxoglutarate), is an intermediate of the Krebs cycle and is the keto acid produced by the deamination of glutamate (Krebs & Eggleston, 1940).
2 Oxoglutaric Acid - an overview | ScienceDirect Topics
2-Oxoglutarate can cyclize to form the lactol 2-hydroxy-5-oxotetrahydrofuran-2-carboxylic acid (Kerber and Fernando, 2010). Alternatively, 2OG can be rapidly hydrated to form a ketal, 2,3-dihydroxypentanedioic acid.
The Antioxidative Function of Alpha-Ketoglutarate and Its …
AKG is a weak acid containing two carboxyl groups and a ketone group which is also called 2-ketoglutaric acid or 2-oxoglutaric acid. AKG possesses many physiological functions. On the one hand, AKG could react with ammonia and then be converted into glutamate; subsequently, the glutamate further reacts with ammonia and generates glutamine ...
Biochemical pathways to α-ketoglutarate, a multi-faceted …
2020年7月20日 · α-Ketoglutarate (AKG) also known as 2-oxoglutarate is an essential metabolite in virtually all organisms as it participates in a variety of biological processes including anti-oxidative defence, energy production, signalling modules, and genetic modification.
2-Oxoglutaric Acid - an overview | ScienceDirect Topics
2012年4月2日 · Due to their biological significance, 2-oxoacids have been synthesized by a variety of chemical and enzymatic schemes (Gault, 1912; Meister, 1957). 2-Oxoglutaric acid and 2-oxoadipic acid are currently available from commercial suppliers (e.g., Sigma-Aldrich).