Berberine: A Review of its Pharmacokinetics Properties and …
Owing to its strong antioxidative and anti-inflammatory activities, oral administration of berberine (200 mg/kg) conferred cardioprotective effects in rats by improving post-MI/R cardiac function recovery and reducing infarct size after MI/R injury; the mechanism of action was found to be associated with the regulation of the SIRT-1 signaling ...
Metformin and berberine, two versatile drugs in treatment of …
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action.
Berberine, a Herbal Metabolite in the Metabolic Syndrome: The …
Berberine acts as an anticancer option by inducing apoptosis, the cell cycle arrest, influencing MAPK (mitogen-activated protein kinase), and influencing transcription regulation. The inhibition of carcinogenesis is also combined with lipid metabolism.
Effects and mechanisms of berberine in diabetes treatment
2012年8月1日 · Berberine is known as an AMP-activated protein kinase (AMPK) activator. Its insulin-independent hypoglycemic effect is related to inhibition of mitochondrial function, stimulation of glycolysis and activation of AMPK pathway. Additionally, berberine may also act as an α -glucosidase inhibitor.
Berberine: Uses, Interactions, Mechanism of Action - DrugBank …
2005年6月13日 · Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells.
Inhibition of inflammation by berberine: Molecular mechanism …
2024年6月1日 · The molecular mechanism of action of berberine was shown in Fig. 1. In conclusion, berberine impacted cytokine production and released through various mechanisms. And berberine inhibited the NF-κB, MAPK signaling …
Biological properties and clinical applications of berberine
Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease.
Berberine - an overview | ScienceDirect Topics
Berberine stabilizes LDLR mRNA via activating regulatory proteins located downstream of the extracellular signal regulated kinase (ERK) pathway which interact with the proximal sequences in the 3′ untranslated region (UTR) of the LDLR mRNA [62].
A Descriptive Review of the Antioxidant Effects and Mechanisms …
2024年9月26日 · Berberine, an alkaloid derived from various plants in the Berberidaceae family, enhances cellular defenses against oxidative stress through several mechanisms. It activates the AMP-activated protein kinase (AMPK) pathway, which reduces mitochondrial reactive oxygen species (ROS) production and improves energy metabolism.
Molecular mechanisms, targets and clinical potential of berberine …
2024年6月18日 · As natural isoquinoline alkaloid, berberine (BBR) has shown great promise in regulating glucose and lipids metabolism and treating metabolic disorders. However, the related mechanism still lacks systematic research.