Cdc25 - Wikipedia
Cdc25 activates cyclin dependent kinases by removing phosphate from residues in the Cdk active site. In turn, the phosphorylation by M-Cdk (a complex of Cdk1 and cyclin B ) activates Cdc25. Together with Wee1 , M-Cdk activation is switch-like.
The role of CDC25C in cell cycle regulation and clinical ...
As an important cell cycle regulatory protein, Cell Division Cycle 25C (CDC25C) participates in regulating G2/M progression and in mediating DNA damage repair.
Phosphatases and Kinases Regulating CDC25 Activity in the ...
CDC25, dual specificity phosphatase (DSP), is an important checkpoint component, and dysregulation of CDC25 can contribute to genomic instability. Genomic instability occurs when cell continues to divide and the DNA lesion is passed to daughter cells due to …
CDC25 phosphatases in cancer cells: key players ... - Nature
Cell division cycle 25 (CDC25) phosphatases are key regulators of the eukaryotic cell cycle. They are required to control cyclin-dependent kinase (CDK) dephosphorylation and activation in a...
The role of Cdc25A in the regulation of cell proliferation ...
Cdc25A activates cyclin D-CDK4 complex and cyclin E-CDK2 complex, which phosphorylate Rb and dissociate Rb from complex with E2F1, releasing inhibition on E2F1, whose activity is essential for G 1 /S transition.
Cdc25 Phosphatases and Cancer: Chemistry & Biology - Cell Press
The Cdc25 phosphatases function as key regulators of the cell cycle during normal eukaryotic cell division and as mediators of the checkpoint response in cells with DNA damage. The role of Cdc25s in cancer has become increasingly evident in recent years.
Cdc25 and the importance of G 2 control - National Center for ...
2014年7月7日 · Here we discuss the role of Cdc25, a key regulator of mitotic entry, with a focus on several recent examples that show how the precise control of Cdc25 activity and the G 2 /M transition are critical for different aspects of embryogenesis.