The concurrent chemoradiation paradigm—general principles
Significant contributions have been made by technological improvements in radiotherapy, as well as by the introduction of novel chemotherapy agents and dosing schedules. This article will review...
Concurrent once-daily versus twice-daily chemoradiotherapy in …
Concurrent chemoradiotherapy is the standard of care in limited-stage small-cell lung cancer, but the optimal radiotherapy schedule and dose remains controversial. The aim of this study was to establish a standard chemoradiotherapy treatment regimen in limited-stage small-cell lung cancer.
Concomitant Chemoradiotherapy | Journal of Clinical Oncology
2007年9月10日 · A concurrent chemoradiotherapy regimen represents the best current standard therapy option for many patients with regionally advanced solid tumors, and improves the probability of cure. The general clinical goal of administering chemotherapy and radiation simultaneously is to improve both locoregional and systemic tumor control.
Concurrent Chemoradiation ± Atezolizumab (atezo) in Limited …
2024年10月1日 · Concurrent chemoradiation (cCRT) followed by prophylactic cranial irradiation (PCI) has been the standard of care for LS-SCLC for decades. NRG-LU005 (NCT03811002) tested the addition of atezo to cCRT in this open label, randomized phase III international trial.
Concurrent vs sequential chemoradiotherapy for patients with …
Chemotherapy in combination with thoracic radiotherapy yields significant results in patients with advanced non–small-cell lung cancer (NSCLC) compared with thoracic radiotherapy alone. However, whether concurrent or sequential delivery of chemotherapy combined with thoracic radiotherapy is optimal remains unclear.
The Concurrent Chemoradiation Paradigm - Medscape
Three clinical rationales support the use of chemotherapy delivered concurrently with radiation. First, concomitant chemoradiotherapy can be used with organ-preserving intent, resulting in...
Timing of radiotherapy and chemotherapy start for patients …
The use of concurrent chemoradiation is now an established paradigm for patients with locally advanced head and neck cancer for definitive treatment. Cisplatin was initially designed to be administered at a dose of 100 mg/m 2 every 3 weeks for three total doses during the course of …
The concurrent chemoradiation paradigm--general principles
This article will review the rationale for the use of concurrent chemoradiotherapy for treating malignancies. The molecular basis and mechanisms of action of combining classic cytotoxic agents (e.g. platinum-containing drugs, taxanes, etc.) and novel agents (e.g. tirapazamine, EGFR inhibitors and other targeted agents) with radiotherapy will be ...
Sequential and Concurrent Chemoradiation: State of the Art
Most patients diagnosed with head and neck cancer have locally advanced disease. Sequential and concurrent chemoradiation are standard, nonsurgical, curative-intent treatment options. Controversy remains regarding the superiority of one approach to another.
Concurrent Chemoradiotherapy in Stage III Non–Small-Cell …
2015年1月5日 · The accepted standard treatment for inoperable stage III non–small-cell lung cancer (NSCLC) today typically consists of concurrent chemoradiotherapy that is based on so-called platinum-doublet chemotherapy. 1–3 The majority of treatment centers administer cumulative radiation doses between 60 and 66 Gy in conventionally fractionated ...
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