Monoacylglycerol lipase reprograms lipid precursors signaling in …
2020年7月7日 · Monoacylglycerol lipase represent a crossroad between cannabinoid and lipid signaling pathways. Monoacylglycerol lipase is the key enzyme degrading the endogenous cannabinoid ligand 2-AG, which in turn is able to bind either cannabinoid receptor (CB) -1r or -2r.
Robust anti‐nociceptive effects of monoacylglycerol lipase …
2016年9月23日 · We evaluated the effects of a potent and selective monoacylglycerol (MAG) lipase inhibitor (MJN110) on OA pain behaviour, spinal mechanisms of action and joint histopathology in the rat. Intra‐articular injection of monosodium iodoacetate (MIA) models OA pain and mimics clinical joint pathology.
Monoacylglycerol lipase regulates a fatty acid network that …
2010年1月1日 · We show that MAGL, through hydrolysis of monoacylglycerols (MAGs), controls free fatty acid (FFA) levels in cancer cells. The resulting MAGL-FFA pathway feeds into a diverse lipid network enriched in pro-tumorigenic signaling molecules and promotes migration, survival, and in vivo tumor growth.
Here, we show that the enzyme monoacylglycerol lipase (MAGL) is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a fatty acid network enriched in oncogenic signaling lipids that promotes migration, invasion, survival, and in …
A monoacylglycerol lipase inhibitor showing therapeutic efficacy …
2023年12月5日 · Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is...
A novel monoacylglycerol lipase-targeted - Nature
2022年5月5日 · Monoacylglycerol lipase (MAGL), a 33 kDa serine hydrolase, is a key degrading enzyme of 2-arachidonoylglycerol (2-AG) in the endocannabinoid system and releases arachidonic acid (AA) in the...
Characterization of monoacylglycerol lipase inhibition reveals ...
2009年7月31日 · Monoacylglycerol lipase (MAGL) is a principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). We recently reported a piperidine carbamate, JZL184, that inhibits MAGL with high potency and selectivity. Here, we describe a comprehensive mechanistic characterization of JZL184. …
Robust anti-nociceptive effects of MAG lipase inhibition in a …
We evaluated the effects of a potent and selective MAG lipase inhibitor (MJN110) on OA pain behaviour, spinal mechanisms of action and joint histopathology in the rat. Experimental approach: Intra-articular injection of monosodium iodoacetate (MIA) models OA pain and mimics clinical joint pathology.
Monoacylglycerol lipase inhibition by organophosphorus compounds …
2006年2月15日 · MAG lipase is increasingly viewed as a major factor in the cannabinoid system (Hohmann et al., 2005), along with FAAH (McKinney and Cravatt, 2005). MAG lipase is unique among the lipases in using only monoacylglycerols as substrates (Karlsson et al., 2000), and the highest levels of MAG lipase mRNA occur in brain regions where CB1 receptor is ...
Monoacylglycerol Lipase Regulates a Fatty Acid Network that …
2010年1月8日 · We show that MAGL, through hydrolysis of monoacylglycerols (MAGs), controls free fatty acid (FFA) levels in cancer cells. The resulting MAGL-FFA pathway feeds into a diverse lipid network enriched in protumorigenic signaling molecules and promotes migration, survival, and in vivo tumor growth.