Creatine - Wikipedia
Creatine is a naturally occurring non-protein compound and the primary constituent of phosphocreatine, which is used to regenerate ATP within the cell. 95% of the human body's total creatine and phosphocreatine stores are found in skeletal muscle, while the remainder is distributed in the blood, brain, testes, and other tissues. [18][19] The typ...
Creatine and Creatinine Metabolism | Physiological Reviews
2000年7月1日 · The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inherent implications for physiology and human ...
Metabolic Basis of Creatine in Health and Disease: A ...
Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target cells through a specific symporter called Na + /Cl − -dependent Cr transporter (CRT).
Creatine metabolism: energy homeostasis, immunity and cancer ...
2020年6月3日 · In adipose tissue, creatine controls thermogenic respiration and loss of this metabolite impairs whole-body energy expenditure, leading to obesity. We also cover the various roles that creatine...
Creatine metabolism: energy homeostasis, immunity and …
In adipose tissue, creatine controls thermogenic respiration and loss of this metabolite impairs whole-body energy expenditure, leading to obesity. We also cover the various roles that creatine metabolism has in cancer cell survival and the function of the immune system.
Creatine and creatinine metabolism - PubMed
The goal of this review is to present a comprehensive survey of the many intriguing facets of creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr biosynthesis and degradation, species and tissue distribution of the enzymes and metabolites involved, and of the inhe …
Biomarkers of Creatine Metabolism in Humans: From Plasma to ...
4 天之前 · The literature on creatine biomarkers in various bodily fluids remains limited. The purpose of this review is to explore the available data regarding the presence of molecules considered biomarkers of creatine metabolism—namely creatine, guanidinoacetate, and creatinine—across different bodily fluids and matrices. In addition to providing reference values for each biofluid, the paper ...
Beyond Muscles: The Untapped Potential of Creatine - PMC
Creatine is naturally synthesized in the liver, kidney, and pancreas of vertebrates from the amino acids arginine, methionine, and glycine [1–3]. In vivo, creatine is a product of the arginine biosynthesis pathway and metabolizes to creatinine [3,4].
Metabolic Basis of Creatine in Health and Disease: A ...
2021年4月9日 · Creatine (Cr) is a ubiquitous molecule that is synthesized mainly in the liver, kidneys, and pancreas. Most of the Cr pool is found in tissues with high-energy demands. Cr enters target cells through a specific symporter called Na + /Cl--dependent Cr transporter (CRT).
In adipose tissue, creatine controls thermogenic respiration and loss of this metabolite impairs whole- body energy expenditure, leading to obesity. We also cover the various roles that creatine...