Cysteine Oxidation in Proteins: Structure, Biophysics, and …
We present an analysis of the role of cysteine reactivity as a regulatory factor in proteins, emphasizing the interplay between electrostatics and redox potential as key determinants of the resulting oxidation state.
Cysteine Oxidation in Proteins: Structure, Biophysics, and …
We present an analysis of the role of cysteine reactivity as a regulatory factor in proteins, emphasizing the interplay between electrostatics and redox potential as key determinants of the resulting oxidation state.
Mechanisms and consequences of protein cysteine oxidation: …
2020年2月17日 · Thiol groups in protein cysteine (Cys) residues can undergo one- and two-electron oxidation reactions leading to the formation of thiyl radicals or sulfenic acids, respectively. In this mini-review we summarize the mechanisms and kinetics of the formation of these species by biologically relevant ox …
Cysteine Is the Only Universally Affected and Disfavored …
Thus, cysteine one-electron oxidation or a related type of oxidation may account at least in part for the very low degree of conservation of solitary surface cysteine residues, as opposed to paired cysteine residues, in the general proteome [13,14], since disulfides are much more resistant to one-electron oxidation and less damaging in the one ...
Proteome-wide analysis of cysteine oxidation reveals metabolic ... - Nature
2018年4月20日 · Reactive oxygen species (ROS) are increasingly recognised as important signalling molecules through oxidation of protein cysteine residues. Comprehensive identification of redox-regulated...
A Quantitative Tissue-Specific Landscape of Protein Redox …
2020年3月5日 · Global cysteine oxidation profiles were remarkably consistent across biological replicates in most tissues, with the large majority of cysteines exhibiting reproducible extents of modification in a given tissue (Figures S2B and S2C).
Cysteine Oxidation - Chemical & Engineering News
2009年10月5日 · Cysteine sulfenic acid (–SOH) is the initial product of oxidation of cysteine by cellular reactive oxygen species such as hydrogen peroxide.
Introduction to approaches and tools for the evaluation of protein ...
Oxidatively modified cysteinyl residues in proteins play an important part role in the redox regulation of cell signaling and metabolism, and the identification of the sites and modifications that underlie these regulatory events is of great importance.
Expanding the functional diversity of proteins through cysteine oxidation
2008年12月1日 · Cysteine oxidation, leading to the formation of covalent disulfide bridges, can modulate protein structure and function. Moreover, disulfides are reversible through the action of cellular reductants such as glutathione (GSH) and thioredoxin (Trx).
Cysteine Oxidation in Proteins: Structure, Biophysics, and
2022年10月18日 · We present an analysis of the role of cysteine reactivity as a regulatory factor in proteins, emphasizing the interplay between electrostatics and redox potential as key determinants of the resulting oxidation state.