Human Gene Set: BIOCARTA_EGF_PATHWAY - GSEA-MSigDB
EGF Signaling Pathway: Full description or abstract: The epidermal growth factor (EGF) peptide induces cellular proliferation through the EGF receptor, which has a tyrosine kinase cytoplasmic domain, a single transmembrane domain and an extracellular domain involved in EGF binding and receptor dimerization.
Mouse Gene Set: WP_EGFR1_SIGNALING_PATHWAY - GSEA …
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EGF Signaling | GeneGlobe - Qiagen
The epidermal growth factor (EGF) family is a group of structurally related proteins that regulate cell proliferation, migration and differentiation, via tyrosine kinase receptors on target cells. The EGF receptor has a cytoplasmic tyrosine kinase domain, a transmembrane domain and an extracellular domain that binds to EGF.
egf signaling pathway Gene Set - maayanlab.cloud
20 proteins participating in the egf signaling pathway pathway from the Biocarta Pathways dataset. Search for genes and functional terms extracted and organized from over a hundred publicly available resources.
Gene Set - EGF/EGFR Signaling Pathway (Homo sapiens)
161 proteins participating in the EGF/EGFR Signaling Pathway (Homo sapiens) pathway from the Wikipathways Pathways dataset. Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins.
DNA damage alters EGFR signaling and reprograms cellular
2022年4月6日 · Here, we show that in damaged cells, the expression of Mig-6 (mitogen-inducible gene 6), a known regulator of EGFR signaling, is reduced resulting in heightened EGFR phosphorylation and...
Epidermal Growth Factor Receptor Cell Proliferation Signaling …
We focus on the induction of CYCLIN D expression, CDK4/6 activation, and the repression of cyclin-dependent kinase inhibitor proteins (CDKi) by EGFR signaling pathways. We also discuss the successes and challenges of EGFR-targeted therapies, and the potential for their use in combination with CDK4/6 inhibitors.
A comprehensive pathway map of epidermal growth factor receptor signaling
In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways. The map reveals that the overall architecture of the pathway is a bow-tie (or hourglass) structure with several feedback loops.
Multimodal scanning of genetic variants with base and prime …
2024年11月12日 · Toward identifying pathogenic EGFR variants that lead to constitutive EGFR signaling in MCF10A cells, we compared sgRNA library distributions in nontreated and EGF-deprived cells.
A comprehensive pathway map of epidermal growth factor receptor signaling
2005年5月25日 · The map includes EGFR endocytosis followed by its degradation or recycling, small guanosine triphosphatase (GTPase)‐mediated signal transduction such as mitogen‐activated protein kinase (MAPK) cascade, phosphatidylinositol polyphosphate (PIP) signaling, cell cycle, and G protein‐coupled receptor (GPCR)‐mediated EGFR transactivation via ...