Epigenetic therapy - Wikipedia
Epigenetic therapy refers to the use of drugs or other interventions to modify gene expression patterns, potentially treating diseases by targeting epigenetic mechanisms such as DNA methylation and histone modifications.
Epigenetic Therapies for Cancer | New England Journal of …
2020年8月12日 · Epigenetic therapies seek to normalize DNA methylation patterns and post-translational modifications on histones that promote or maintain a malignant phenotype.
Cancer epigenetics: from laboratory studies and clinical trials to ...
2024年1月15日 · The main objective of epigenetic therapy in the era of personalized precision medicine is to detect cancer biomarkers to improve risk assessment, diagnosis, and targeted treatment interventions.
Advances in epigenetic therapeutics with focus on solid tumors
2021年4月20日 · In this review, we describe mechanisms of various epigenetic modifications, discuss the Food and Drug Administration-approved epigenetic agents, and focus on the current clinical investigations of novel epigenetic monotherapies and combination therapies in …
Targeting epigenetic regulators for cancer therapy: mechanisms …
2019年12月17日 · With the development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited...
Epigenetic Therapy - an overview | ScienceDirect Topics
Epigenetic Therapy. The use of drugs to correct epigenetic defects, referred to as epigenetic therapy, is a new and rapidly developing area of pharmacology. Compared to genetic defects, which are permanent, epigenetic defects are more …
Epigenetic therapy in immune-oncology | Nature Reviews Cancer
2019年2月5日 · In this Review, we outline these recent discoveries showing that epigenetic therapies as exemplified by DNMTi can act to increase the immunogenicity of cancer cells, reshape the immune TME and...
Epigenetic therapies seek to normalize DNA methylation patterns and post-translational modifications on histones that promote or maintain a malignant phenotype.
Cancer epigenetic therapy: recent advances, challenges, and …
2024年8月20日 · Epigenetic dysregulation is an important nexus in the development and maintenance of human cancers. This review provides an overview of how understanding epigenetic dysregulation in cancers has led to insights for novel cancer therapy development.
Epigenetic Therapy | How it Works, Risks & Benefits - MAA Center
2022年12月9日 · Epigenetic therapy is a promising emerging treatment for mesothelioma and other cancers. Discover how it works and the risks and benefits involved.
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