FTY720, a new class of immunomodulator, inhibits lymphocyte ... - PubMed
The chemical modification of ISP-I yielded a new compound, FTY720, which has more potent immunosuppressive activity and less toxicity than ISP-I does. FTY720 has been shown to be highly effective in experimental allotransplantation models and autoimmune disease models.
Fingolimod (FTY720): discovery and development of an oral drug …
2010年10月29日 · The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory drug, has opened up new approaches to the treatment of multiple sclerosis, the most common...
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
2006年9月14日 · Fingolimod (FTY720) is a new oral immunomodulating agent under evaluation for the treatment of relapsing multiple sclerosis. We randomly assigned 281 patients to receive oral fingolimod, at a...
Characterization of the effects of immunomodulatory drug fingolimod ...
2018年7月19日 · Fingolimod (FTY720) is an FDA approved immunomodulatory drug for treating multiple sclerosis that inhibits lymphocyte egress from lymphoid tissues by down regulating sphingosine-1 phosphate...
FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of …
The novel immunomodulator FTY720 is effective in experimental models of transplantation and autoimmunity, and is currently undergoing Phase III clinical trials for prevention of kidney graft rejection.
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes …
2023年12月26日 · FTY720 (fingolimod) is a sphingosine 1-phosphate (S1P) receptor modulator and sphingosine analog approved for MS therapy that can functionally antagonize S1P 1. Here, we report that FTY720 suppresses neuroinflammation by functionally and physically regulating the B …
The emerging role of FTY720 (Fingolimod) in cancer treatment
2016年4月26日 · FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor.
FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function ...
2023年4月17日 · FTY720 is an FDA-approved sphingosine derivative drug for the treatment of multiple sclerosis. This compound blocks lymphocyte egress from lymphoid organs and autoimmunity through sphingosine 1-phosphate (S1P) receptor blockage.
FTY720: a novel transplantation drug that modulates lymphocyte …
2000年2月1日 · The novel immunomodulator FTY720 is a synthetic structural analogue of myriocin, a metabolite of the ascomycete Isaria sinclairii1–4.
Fingolimod Limits Acute Aβ Neurotoxicity and Promotes ... - Nature
2017年1月30日 · Fingolimod, also known as FTY720, is an analogue of the sphingolipid sphingosine, which has been proved to be neuroprotective in rodent models of Alzheimer’s disease (AD). Several cellular and...
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