Overview of the IL-1 family in innate inflammation and acquired ...
The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other cytokine family, the IL-1 family is primarily associated with innate immunity.
The IL-1 family: regulators of immunity - Nature
2010年1月18日 · IL-1 family members promote the activity of cells of the innate immune system, such as neutrophils, eosinophils, basophils, mast cells and natural killer cells. IL-1 family members also...
THE INTERLEUKIN-1 FAMILY: BACK TO THE FUTURE - PMC
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes 7 ligands with agonist activity (IL-1α and β, IL-18, IL-33, IL-36α, β, γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38) and an anti-inflammatory cytokine (IL-37).
The IL-1 family: regulators of immunity - PubMed
Among the most potent molecules of the innate immune system are the interleukin-1 (IL-1) family members. These evolutionarily ancient cytokines are made by and act on innate immune cells to influence their survival and function.
Inflammasome signaling and regulation of interleukin-1 family …
Specific IL-1 family cytokines are expressed by cells as cytosolic pro-forms that require cleavage for their activity and cellular release. IL-1β, IL-18, and IL-37 maturation and secretion is governed by inflammatory caspases within signaling platforms called inflammasomes.
International nomenclature guidelines for the IL-1 family of …
2024年3月18日 · Here, we propose a nomenclature for both receptors and cytokines in the IL-1 family, based on common accepted practice and previous proposals 2, 3. We hope that this updated classification...
The Interleukin-1 Family: Back to the Future - ScienceDirect
2013年12月12日 · Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37).
New Insights in the Immunobiology of IL-1 Family Members
2013年7月8日 · The interleukin-1 (IL 1) family of ligands is associated with acute and chronic inflammation, and plays an essential role in the non-specific innate response to infection. The biological properties of IL 1 family ligands are typically pro-inflammatory.
Interleukin-1 (IL-1) Pathway | Science Signaling - AAAS
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes (IL1A, IL1B, IL1RN, IL18, and IL1F5 to IL1F11 in humans, Il1A to Ilf11 in mice) (1–3).
The Roles of IL-1 Family Cytokines in the Pathogenesis of …
2019年8月9日 · The interleukin (IL)-1 family is a group of 11 proinflammatory and anti-inflammatory cytokines. Recent findings show that expression of most IL-1 family cytokines, such as IL-1α, IL-1β, IL-18, and IL-33, was abnormal in many autoimmune diseases including SSc.
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