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  1. Cell Signaling Technology (CST)
    https://www.cellsignal.cn/pathways/cell-intrinsic...

    细胞固有天然免疫信号转导 | Cell Signaling Technology

  2. IRF3 通路的图片

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  3. 知乎专栏
    https://zhuanlan.zhihu.com/p/478402177

    cGAS-STING 信号通路发现史（上） - 知乎专栏

    标记:
    Cgas
    STING信号通路
  4. Nature
    https://www.nature.com/articles/nri1900

    IRFs: master regulators of signalling by Toll-like receptors and ...

    标记:
    Kenya Honda, Tadatsugu Taniguchi
    Publish Year:2006
    Nature Reviews Immunology
  5. Science | AAAS
    https://www.science.org/doi/10.1126/sciadv.…

    IRF3 inhibits inflammatory signaling pathways in …

    2024年8月9日 · Here, we used conditional Irf3 knockout (Irf3 Δ/Δ) and macrophage-specific Irf3 knockout (Irf3 MKO) mice to evaluate the role of IRF3 in preventing viral inflammation and pathogenesis. Irf3 Δ/Δ mice, upon …

    标记:
    IRF3
    Science
  6. Nature
    https://www.nature.com/articles/s41392-024-01980-4

    The multiple roles of interferon regulatory factor family in health …

  7. Abcam中文官网
    https://www.abcam.cn/help/interferon-regulatory-factor-3-irf3

    IRF3 靶点介绍及实验小贴士 | abcam 中文官网

  8. 其他用户还问了以下问题
    Does IRF3 inhibit inflammatory signaling pathways in irf3mko lungs?
    RNA-seq analyses revealed enhanced NF-κB–dependent gene expression along with activation of inflammatory signaling pathways in infected Irf3MKO lungs. Targeted analyses revealed activated MAPK signaling in Irf3MKO lungs. Therefore, IRF3 inhibited inflammatory signaling pathways in macrophages to prevent viral inflammation and pathogenesis.

    IRF3 inhibits inflammatory signaling pathways in macrophages ... - Scie…

    science.org
    What is IRF3 deficiency?
    Irf3, expressed ubiquitously, is an essential transcription factor, which gets activated rapidly in the virus-infected cells for inducing IFN-β. Irf3 deficiency, as a result, leads to increased viral replication and lethality.

    IRF3 inhibits inflammatory signaling pathways in macrophages ... - Scie…

    science.org
    How is IRF3 expressed?
    IRF3 is constitutively expressed. It resides in the cytosol in latent form and undergoes nuclear translocation following viral infection. Before this translocation, specific serine residues in the C-terminal (regulatory) region are phosphorylated, which is a crucial step.

    IRFs: master regulators of signalling by Toll-like receptors and

    nature.com
    Where is inactive IRF3 located?
    Inactive IRF3, which is located in the cytoplasm of most cells, is exposed to both phosphorylation and dimerization upon viral infection that allow for its nuclear translocation and subsequent transactivation of TI-IFN genes , .

    Regulation of IRF3 activation in human antiviral signaling pathways

    sciencedirect.com
    Does IRF3 deficiency affect inflammatory gene expression?
    Irf3Δ/Δ mice, upon respiratory virus infection, showed increased susceptibility and mortality. Irf3 deficiency caused enhanced inflammatory gene expression, lung inflammation, immunopathology, and damage, accompanied by increased infiltration of pro-inflammatory macrophages.

    IRF3 inhibits inflammatory signaling pathways in macrophages ... - Scie…

    science.org
    What is IRF3 activation of virus sensing?
    IRF3 activation of virus sensing is one of the most important signaling pathways for TI-IFN induction. It is chiefly activated through TLR3, RIG-I and cGAS sensors which involve the adaptor proteins TRIF, MAVS and STING, respectively.

    Regulation of IRF3 activation in human antiviral signaling pathways

    sciencedirect.com
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  9. Nature
    https://www.nature.com/articles/s41417-02…

    Downstream STING pathways IRF3 and NF-κB …

    2023年11月21日 · IRF3 is one of two transcription factors downstream of the STimulator of INterferon Genes (STING), a hub adaptor protein through which multiple dsDNA sensors transmit their signals.

    标记:
    Cancer
    Gene therapy
  10. Science | AAAS
    https://www.science.org/doi/10.1126/scien…

    Phosphorylation of innate immune adaptor proteins …

    2015年1月29日 · In vitro IRF3 IP revealed that the entire IRF3 C terminus (190 to 427, IRF3-C), containing the IRF3 association domain and the serine-rich region, is necessary and sufficient for MAVS binding (fig. S6, A and B). IRF3-C crystal …

    标记:
    Publish Year:2015
  11. ScienceDirect
    https://www.sciencedirect.com/science/article/pii/S0006295222001204

    Regulation of IRF3 activation in human antiviral signaling pathways

    标记:
    IRF3
    Cgas
  12. 中国科学院
    https://www.cas.cn/ky/kyjz/201404/t2014…

    上海生科院揭示负调控I型干扰素信号通路的新机制

    该研究首次揭示了一种普遍存在的irf3失活的新机制，为整个干扰素调节因子超家族（irf）的研究提供了新思路；也为i型干扰素紊乱相关疾病（自身免疫性疾病和败血症等）的治疗提供了新策略。

    标记:
    IRF3
    干扰素信号通路的新机制