Department of Defense (DoD) Impact Level 4 (IL4)
2023年4月4日 · DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and …
Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …
IL4 Gene - GeneCards | IL4 Protein | IL4 Antibody
2024年10月2日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …
Recent advances in understanding the role of IL-4 signaling
2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, …
Recent advances in understanding the role of IL-4 signaling
STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).
IL4 interleukin 4 [Homo sapiens (human)] - Gene - NCBI
6 天之前 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. …
Regulation of inflammation by interleukin-4: a review of …
The IL-4R is composed of two transmembrane proteins. IL-4Rα chain (red) binds IL-4 (blue) with high affinity, leading to dimerization with γ c (yellow) or IL-13Rα1 (green), forming the type I or …
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8 - Nature
2024年9月25日 · Interleukin-4 (IL-4), a prototypical type 2 cytokine, has been reported to prolong the survival of T and B lymphocytes 15,16.Here we proposed that IL-4 could rejuvenate the …
COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING - PMC
SNPs in IL4, IL13 and the receptor subunits are reportedly associated with glioma (111, 112). These polymorphisms highlight key features of IL-4/-13 receptor signaling that regulate …
Regulation of IL4 gene expression by T cells and therapeutic ...
2003年7月1日 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated …