哇！单细胞测序-配体受体互作分析原来可以这么简单又高大上！
我们采用的配受体数据库来自Ramilowski等人于2015年在Nature communication上发表的A draft network of ligand-receptor-mediated multicellular signalling in human描述的一组配体和受体。我们建议使用此数据集作为起点，并整理自己的已知配体和受体列表。
Physiology, Cellular Receptors - StatPearls - NCBI Bookshelf
2024年9月19日 · When a water-soluble ligand binds to a cell-surface receptor, it activates the receptor, initiating a signal transduction pathway that alters cellular function. The 3 types of cell-surface receptors include G protein–coupled receptors (GPCRs), ion channel receptors, and enzyme-linked receptors.
14.2: Receptors and Ligands - Biology LibreTexts
A receptor is defined as a protein that binds to an extracellular ligand, and then undergoes a conformational or biochemical shift in such a way that it initiates a chain of intracellular events by which the cell reacts to the extracellular signal.
Deciphering cell–cell interactions and communication from gene ...
2020年11月9日 · In particular, ligand–receptor pairs can be used to infer intercellular communication from the coordinated expression of their cognate genes. In this Review, we highlight discoveries enabled by...
A draft network of ligand–receptor-mediated multicellular ... - Nature
2015年7月22日 · We reveal that most cells express tens to hundreds of ligands and receptors to create a highly connected signalling network through multiple ligand–receptor paths. We also observe extensive...
Signals and Receptors - PMC - PubMed Central (PMC)
Ligand-activated receptors convey signals into the cell by activating signaling pathways that ultimately affect cytosolic machineries or nuclear transcriptional programs or by directly translocating to the nucleus to regulate transcription.
Signaling Molecules and Their Receptors - The Cell - NCBI …
Many different kinds of molecules transmit information between the cells of multicellular organisms. Although all these molecules act as ligands that bind to receptors expressed by their target cells, there is considerable variation in the structure and function of the different types of molecules that serve as signal transmitters.
Identification of ligand–receptor pairs that drive human ... - Nature
2023年7月17日 · Here we used published transcriptomic data to identify and functionally test five ligand–receptor pairs that synergistically drive human astrogenesis. We validate the synergistic contributions of...
Receptor-ligand interactions: Advanced biomedical applications
2016年11月1日 · Various ligand-receptor pairs and RLIs of living cells can be used to create so-called smart biomaterials for a plenty of physicochemical and biomedical applications in the fields of life sciences, industrial biotechnology and pharmacology, tissue engineering, design of highly sensitive diagnostic tools, etc.
Insights into Protein–Ligand Interactions: Mechanisms, Models, …
The protein receptor molecules are immobilized on the sensor surface, and the ligand (usually called the analyte molecule) is injected into the aqueous solution to detect the binding reaction. As ligands bind to immobilized receptor molecules, an increase in the refractive index (expressed in response units, RU) is observed.