Let’s talk about lipid nanoparticles | Nature Reviews Materials
2021年2月9日 · Lipid nanoparticles are spherical vesicles made of ionizable lipids, which are positively charged at low pH (enabling RNA complexation) and neutral at physiological pH (reducing...
Lipid-based nanoparticle - Wikipedia
Lipid-based nanoparticles are very small spherical particles composed of lipids. They are a novel pharmaceutical drug delivery system (part of nanoparticle drug delivery), and a novel pharmaceutical formulation.
Lipid nanoparticles for mRNA delivery - Nature Reviews Materials
2021年8月10日 · In this Review, we discuss the design of lipid nanoparticles for mRNA delivery and examine physiological barriers and possible administration routes for lipid nanoparticle–mRNA systems.
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery ...
2021年6月28日 · Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of the COVID-19 mRNA vaccines, LNPs play a key role in effectively protecting and transporting mRNA to cells.
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview ...
2023年8月21日 · In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential.
Comprehensive analysis of lipid nanoparticle formulation and ...
Lipid nanoparticles (LNPs) are promising delivery carriers that provide RNA stability, with strong transfection efficiency, favorable and tailorable pharmacokinetics, limited toxicity, and established translatability.
Acid-degradable lipid nanoparticles enhance the delivery of ...
2024年8月23日 · Acid-degradable lipids composed of polyethylene glycol lipids, anionic lipids and cationic lipids were synthesized with the azido-acetal linker and used to generate RD-LNPs, which...