Current State of Animal (Mouse) Modeling in Melanoma Research
In this article, besides traditional mouse models of melanoma, we will discuss recent ones, such as patient-derived tumor xenografts, topically inducible BRAF mouse model and RCAS/TVA-based model, and their advantages as well as limitations.
A new mouse model of melanoma progression | Lab Animal
2019年12月16日 · Using a novel mouse model, a study published in Nature Communications provides new insights into melanoma progression, thereby opening new avenues for the development of diagnostic and...
Pre-clinical modeling of cutaneous melanoma - Nature
2020年6月5日 · In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived...
Genetically Engineered Mouse Models of Melanoma - PMC
Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma.
A novel immunogenic mouse model of melanoma for the …
2019年2月4日 · Here, we describe YOVAL1.1 as a novel mouse model of melanoma that is suitable for evaluating in vivo immune interactions in response to targeted therapy. Chicken ovalbumin (OVA) is widely used...
Melanoma models for the next generation of therapies
2021年5月10日 · Here, we discuss the current state of the art of melanoma models including genetically engineered mouse, patient-derived xenograft, zebrafish, and ex vivo and in vitro models. We also identify five major challenges that can be addressed using such models, including metastasis and tumor dormancy, drug resistance, the melanoma immune response ...
Animal models of melanoma: a somatic cell gene delivery mouse model ...
The most widely used syngeneic transplantation melanoma model is B16, which was derived from a chemically induced melanoma arising in a C57BL/6J mouse. While these cells express low levels of major histocompatibility complex class I (MHC I) molecules, they express high levels of melanoma-associated antigens, such as gp100 or tyrosinase related ...
A Spontaneous Melanoma Mouse Model Applicable for a …
2023年10月1日 · In this study, we used a fully immunocompetent, transgenic mouse model, TGS, in which the spontaneous development of metastatic melanoma is driven by the ectopic expression of a normal neuronal receptor, mGluR1, as a model to assess longitudinal treatment response (up to 8 months) with an inhibitor of glutamatergic signaling, troriluzole, which ...
Animal (mouse) models of melanoma - ScienceDirect
2019年1月1日 · A lot of success to available treatments and knowledge of genes involved in melanoma initiation and progression can be attributed to various preclinical mouse models developed in the last decade. In this chapter, we discuss these models and some recent advancement in the preclinical animal models such as PDX models.
Modelling melanoma in mice - PubMed
We examine the relevance of mice as models for human melanoma progression and for key molecular and histopathologic variants of melanoma. These mice may be used as preclinical models to probe the relationships between causative mutations, disease progression and outcome for molecularly targeted therapeutics.