Microtubule-associated protein - Wikipedia
In cell biology, microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs are integral to the stability of the cell and its internal structures and the transport of components within the cell.
Microtubule-Associated Proteins: Structuring the Cytoskeleton
Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a …
Microtubules: Evolving roles and critical cellular interactions
However, some subpopulations of microtubules can be stabilized, a process that involves GTP capping of terminal α-tubulin monomers and is promoted by microtubule associated proteins (MAPs), formins and microtubule plus-end binding proteins (+TIPs) (a, b).
Microtubules and Microtubule-Associated Proteins - PubMed
2018年6月1日 · Dynamic instability allows microtubules to explore intracellular space and remodel in response to intracellular and extracellular cues. Here, we review how such instability is central to the assembly of many microtubule-based structures and to the robust functioning of the microtubule cytoskeleton.
Microtubule-Associated Protein - an overview - ScienceDirect
Microtubule-associated proteins (MAPs) are a heterogeneous group of proteins that have microtubule-binding domains. MAPs are abundantly expressed in the brain, and historically MAPs (e.g., MAP1, MAP2, and tau) derived from the brain have been studied extensively.
Regulation of microtubule dynamics, mechanics and function …
2021年8月18日 · Microtubules are essential, multitasking protein polymers that serve as structural elements in most eukaryotic cells. They are dynamic, and their dynamics are controlled to help organize the...
Microtubule-Associated Proteins: Structuring the Cytoskeleton
2019年8月12日 · Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a large variety of functions.
Effects of three microtubule-associated proteins (MAP2, MAP4
2023年5月31日 · Three microtubule-associated proteins (MAPs), MAP2, MAP4, and tau 4, 5, 6, 7, 8, which are the most well-studied mammalian-derived MAPs with similar primary structures, promote...
The evolution of microtubule associated proteins – a reference ...
Microtubule associated proteins (MAPs), defined as proteins that bind microtubules but are not molecular motors or severing enzymes, play a key role in regulating microtubule stability in neurons. Existing studies of the evolutionary relationships ...
The tubulin code and its role in controlling microtubule ... - Nature
2020年2月27日 · Tubulin isotypes and tubulin PTMs contribute to the assembly of microtubule arrays by modulating their intrinsic properties, as well as their interactions with a multitude of associated proteins.