Monoclonal antibody - Wikipedia
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way …
Chapter 1: Monoclonal Antibodies: Structure, Physicochemical …
2020年3月14日 · Monoclonal antibodies (mAbs) are the largest class of therapeutic proteins. Owing to their versatile structure and function, mAbs are used for a wide range of therapeutic …
Understanding How Monoclonal Antibodies Work
2023年6月26日 · The five antibody classes (as classified by heavy chain sequence) are IgM, IgD, IgG, IgE, and IgA. Each antibody class performs a unique function in human biology. The most …
Molecular and functional analysis of monoclonal antibodies in …
As a complex macro-molecule protein, the molecular characteristics and functions are critical quality attributes for monoclonal antibodies. A series of physicochemical and biological …
The structure of a typical antibody molecule - Immunobiology
Antibody molecules are roughly Y-shaped molecules consisting of three equal-sized portions, loosely connected by a flexible tether. Three schematic representations of antibody structure, …
Structure of Monoclonal Antibodies | SpringerLink
This chapter introduces readers to the chemical structure of antibodies, with specific focus on the structure of immunoglobulin G (IgG). The chapter also highlights functionally important IgG …
Introduction on Monoclonal Antibodies - IntechOpen
2021年6月3日 · Antibody structure and functions: immunoglobulin G as the therapeutic mAb. An antibody molecule has a Y-shaped structure with a total molecular weight of ~150 kDa, …
The structure of a mAb molecule involves one pair of heavy weight polypeptides (heavy chains, HC) of 50 kDa each and one pair of lightweight polypeptides (light chains, LC) of 25 kDa each.
Monoclonal antibody | Definition, Hybridoma, & Human Monoclonal …
2024年10月30日 · antibody structure The four-chain structure of an antibody, or immunoglobulin, molecule. The basic unit is composed of two identical light (L) chains and two identical heavy …
Overview of monoclonal antibodies - ScienceDirect
2021年1月1日 · Structure of monoclonal antibody The basic structure of human mAb is a Y-shaped structure composed of two identical HC and two identical LC, of either kappa (κ) or …