Proliferating cell nuclear antigen - Wikipedia
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
Proliferating cell nuclear antigen (PCNA): a key factor in DNA ...
PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast, plant and animal cells that undergo cell division, suggesting a function in cell cycle regulation and/or DNA replication.
Proliferating cell nuclear antigen (PCNA): a key factor in DNA ...
PCNA exerts a tripartite function by operating as (1) a sliding clamp during DNA synthesis, (2) a polymerase switch factor and (3) a recruitment factor. Most of its functions are mediated by its interactions with various proteins involved in DNA synthesis, repair and recombination as well as in regulation of the cell cycle and chromatid cohesion.
Nuclear Dynamics of PCNA in DNA Replication and Repair
The DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) is central to both DNA replication and repair. The ring-shaped homotrimeric PCNA encircles and slides along double-stranded DNA, acting as a “sliding clamp” that localizes proteins to DNA.
Human PCNA Structure, Function and Interactions - PubMed
2020年4月8日 · : Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes.
Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles...
PCNA structure and function: insights from structures of PCNA …
Proliferating cell nuclear antigen (PCNA), the eukaryotic DNA sliding clamp, forms a ring-shaped homo-trimer that encircles double-stranded DNA. This protein is best known for its ability to confer high processivity to replicative DNA polymerases.
Maneuvers on PCNA Rings during DNA Replication and Repair
2018年8月17日 · Proliferating cell nuclear antigen (PCNA) is the major coordinator of faithful and processive replication and DNA repair at replication forks. Post-translational modifications of PCNA, ubiquitination and acetylation in particular, regulate the dynamics of …
PCNA cycling dynamics during DNA replication and repair in …
2024年6月1日 · Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp that plays multiple roles during chromosome duplication and damaged DNA repair. After the completion of its function, PCNA is unloaded from DNA by a replication factor C-like complex (RLC) called ATAD5-RLC.
PCNA, the Maestro of the Replication Fork - Cell Press
2007年5月18日 · Proliferating cell nuclear antigen (PCNA)—a cofactor of DNA polymerases that encircles DNA—orchestrates several of these functions by recruiting crucial players to the replication fork.