Clades of huge phages from across Earth’s ecosystems | Nature
2020年2月12日 · The tree also includes large terminase sequences from complete RefSeq phage, the Lak megaphage clade 9 (n = 9) and non-artefactual phage genomes that are more than …
The coevolution of large and small terminases of bacteriophages …
2021年12月1日 · Large terminase and small terminase proteins of N4 phage show strong but transient interaction. Genome packaging in many dsDNA phages requires a series of precisely …
A new family of “megaphages” abundant in the marine environment
2021年10月20日 · A Phylogenetic analysis of selected phages and all megaphages (including incomplete megaphage genomes) based on the amino acid sequence of the terminase large …
Diversification of molecular pattern recognition in bacterial NLR …
2024年11月14日 · Type 2 Avs proteins (Avs2) were suggested to recognize the phage large terminase subunit as a signature of phage infection. Here, we show that Avs2 from Klebsiella …
Thousands of previously unknown phages discovered in whole …
2021年3月29日 · The family-rank phage lineages proposed here were defined using a combination of approaches. Principally, phylogenetic analysis of the large terminase subunit …
Bacteriophage Lambda Terminase and the Mechanism of Viral …
As with other terminase enzymes, λ terminase is a heteroligomer composed of small (gpNu1) and large (gpA) subunits (see fig. 3). GpA carries the DNA cutting activity required to initiate and …
The large subunit of bacteriophage λ’s terminase plays a role in …
2002年2月22日 · Previous studies have established a role for the large subunit of bacteriophage λ’s terminase in the early stages of DNA packaging including endonucleolytic cleavage at …
CDD Conserved Protein Domain Family: Terminase_3 - National …
2022年10月17日 · The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit. This region is found on the large subunit and possess an endonuclease and …
Structures of the phage Sf6 large terminase provide new insights …
2013年4月29日 · Here we report the structures of the DNA-packaging motor gp2 of bacteriophage Sf6, which reveal a unique clade of RecA-like ATPase domain and an RNase H-like nuclease …
Large Terminase Conformational Change Induced by Connector …
2013年6月7日 · Here, we report the structures of the T7 pentameric large terminase both isolated and bound to the connector as part of the connector-terminase complex, obtained by electron …