Pyridazine as a privileged structure: An updated review on …
2021年1月1日 · Pyridazine-based analogues 6a and 6b (Fig. 2) possessed moderate inhibitory activities toward colon cancer cell line (HCT116) with the IC 50 values of 39.0 and 30.3 μM, respectively, which was equal to the standard drug imatinib (IC 50 = 34.3 μM).
Pyridazine - an overview | ScienceDirect Topics
2012年6月1日 · Pyridazine is a six-membered heterocyclic compound with two nitrogen atoms at positions 1 and 2. It is known for its broad-spectrum antibacterial, antiviral, and anticancer activities, making it a valuable structure in drug design for developing potential compounds with various biological activities.
Pyridazine - an overview | ScienceDirect Topics
Pyridazine (1,2-diazine) (1) and its benzo analogs cinnoline (1,2-diazanaphthalene) or benzo[c]pyridazine (2) and phthalazine (benzo[d]pyridazine) (3) have been known since the nineteenth century. Although the basic synthetic principles and reactivity were investigated in the early years, interest in these compounds was not very intense ...
Pyridazine as a privileged structure: An updated review on …
2021年1月1日 · Structurally, pyridazine is a highly π-deficient aromatic skeleton and the most basic with pKa = 2.3, which helps protonation, hydrogen bond formation and chelation through nitrogen atoms of the pyridazine ring [4,5].
Pyridazine - an overview | ScienceDirect Topics
2012年8月1日 · Pyridazine-derived ionic liquids, based on a pentafluorosulfanyl group, were also reported <2005EJI2573>. Also prevention of corrosion seems to be an attractive material application <2002MI373, 2004MI4205>. Many polymers containing a 1,2-diazine unit have been reported in the period 1996–2006.
Pyridazine Derivative - an overview | ScienceDirect Topics
2012年6月1日 · Pyridazine is a six-membered heterocyclic compound containing two nitrogen heteroatoms at position 1,2-Pyridazine derivatives excellent broad-spectrum antibacterial, antiviral, and anticancer activities [141–145].
Recent contributions of pyridazine as a privileged scaffold of ...
2024年9月1日 · Structurally, pyridazine is a six-membered heterocyclic ring with two nitrogen atoms in a 1,2-relationship. 2, 3 It exhibits unique physicochemical properties characterized by mild alkalinity (pK a = 2.3), a high dipole moment (μ = 4.22), a highly π-deficient aromatic skeleton that facilitates π-π stacking interactions, and two sp 2 nitrogen atoms that mediate drug-target …
Imidazo[1,2- b ]pyridazines as inhibitors of DYRK kinases
2024年4月5日 · In parallel, efforts are underway to translate the established SAR of the imidazo [1,2-b]pyridazine series to the intrinsically more potent and less lipophilic imidazo [1,2-a]pyridine and imidazo [1,2-a]pyrimidine cores, with the aim of furnishing a compound suitable for use in disease-relevant in vivo models associated with DYRK1A overexpression.
Development of novel antibiotics derived from pyridazine: …
2024年8月1日 · Pyridazine is a commonly synthesized antibiotic that scientists have extensively used to create new antibacterial agents [2], [3]. These compounds have a range of effects, including antispasmodic, antihypertensive, antihistamine, analgesic, anti-inflammatory, and cardiotonic properties with vasodilator activity.
Pyridazine - an overview | ScienceDirect Topics
Pyridazine is a type of heterocyclic compound that serves as a bioisostere for the pyridine system, often used in the design of analogs with variable activities on the central nervous system. AI generated definition based on: The Practice of Medicinal Chemistry (Fourth Edition), 2008
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