RANKL - Wikipedia
RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin …
RANKL biology: bone metabolism, the immune system, and beyond
2020年2月7日 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular …
RANKL - an overview | ScienceDirect Topics
RANKL is a transmembrane molecule expressed by mesenchymal cell and lymphocytes. The soluble form of RANKL is a consequence of proteolytic cleavage. RANKL binds to RANK on …
Biology of RANK, RANKL, and osteoprotegerin - PMC
RANKL is a type II homotrimeric transmembrane protein that is expressed as a membrane-bound and a secreted protein, which is derived from the membrane form as a result of either …
RANKL Biology - PMC
RANKL regulates osteolytic bone metastasis through the stimulation of cancer cell migration toward the bone. RANKL acts directly on RANK-expressing tumor cells and promotes cell …
RANKL-RANK signaling regulates osteoblast differentiation and …
2018年11月27日 · RANKL signaling drives osteoclastogenesis. In BMSCs, RANKL binding to RANK activates RANKL forward signaling, which inhibits osteoblast differentiation.
Biology of the RANKL–RANK–OPG system in immunity, bone, and …
2014年10月19日 · RANKL–RANK–OPG are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies, and share signaling characteristics common to many members of each.
Bone Signaling & RANKL - Basic Science - Orthobullets
2024年7月27日 · RANKL (ligand) is secreted by osteoblasts and binds to the RANK receptor on osteoclast precursor and mature osteoclast cells
RANKL as the master regulator of osteoclast differentiation
2021年1月1日 · RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. …
RANKL biology: bone metabolism, the immune system, and beyond
RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The …