Serotonin transporter - Wikipedia
Neurons communicate by using chemical messengers like serotonin between cells. The transporter protein, by recycling serotonin, regulates its concentration in a gap, or synapse, and thus its effects on a receiving neuron's receptors.
A current view of serotonin transporters - PMC - PubMed Central …
Serotonin transporters (SERTs) are largely recognized for one aspect of their function—to transport serotonin back into the presynaptic terminal after its release. Another aspect of their function, however, may be to generate currents large …
Serotonin Transporter - an overview | ScienceDirect Topics
A serotonin transporter is a protein that is crucial for regulating serotonin function in the brain, playing a key role in various forms of psychopathology and serving as a target for widely prescribed psychotropic medications.
Illumination of serotonin transporter mechanism and role of …
2021年12月1日 · The serotonin transporter (SERT) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders.
Biochemistry, Serotonin - StatPearls - NCBI Bookshelf
2022年10月5日 · The highly selective serotonin transporter (SERT), located on the presynaptic membrane, removes serotonin from the synaptic cleft. Once transported into the presynaptic neuron, serotonin is recycled back into presynaptic vesicles, protected from metabolism.
The 5-Hydroxytryptamine signaling map: an overview of serotonin ...
The serotonin transporter (SERT) is responsible for the reuptake of free 5-HT in the synaptic cleft; this is, in fact, the mechanism of action exploited by selective serotonin reuptake inhibitors (SSRIs), typically used as antidepressants or anxiolytic therapy.
X-ray structures and mechanism of the human serotonin transporter
The serotonin transporter (SERT) terminates serotonergic signaling through the sodium and chloride dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target for antidepressant and psychostimulant drugs, which block …
X-ray structures and mechanism of the human serotonin transporter
2016年4月6日 · The serotonin transporter (SERT) terminates serotonergic signalling through the sodium- and chloride-dependent reuptake of neurotransmitter into presynaptic neurons.
Physiology, Serotonin - StatPearls - NCBI Bookshelf
2023年7月30日 · Serotonin that is recycled back to the cell via serotonin transporter (SERT) is then either stored in vesicles or metabolized by monoamine oxidase (MAO) in the cytoplasm. Peripheral serotonin is metabolized by the liver and lungs.
Ligand coupling mechanism of the human serotonin transporter …
2024年1月10日 · The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter...